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Napa One | 1000mg Tablet
Napa One is indicated for the relief of:
- Fever (including post-vaccination fever in children)
- Common cold and influenza symptoms
- Headache, toothache, earache, body aches, myalgia, neuralgia
- Dysmenorrhoea, sprains, back pain, colic pain, postoperative and postpartum pain
- Pain from inflammation
- Rheumatic and osteoarthritic pain and joint stiffness
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Regular Delivery - 12-24 Hours, Dhaka City*- Regular Delivery - 24-48 Hours, All Over Bangladesh*
ফ্রি ডেলিভারিঃ - ১৪৯৯ টাকা+ অর্ডারে, ঢাকা
শহরে- ফ্রি ডেলিভারিঃ - ৩৪৪৯ টাকা+ অর্ডারে, ঢাকার
বাহিরে
✅ Description:
Paracetamol (Acetaminophen) primarily acts in the central nervous system (CNS) by increasing the pain threshold and reducing fever. It inhibits COX enzymes (COX-1, COX-2, COX-3) involved in prostaglandin synthesis, particularly in the hypothalamus, helping to relieve pain and regulate body temperature. Unlike NSAIDs, it has minimal peripheral anti-inflammatory effects, making it gentler on the stomach and suitable for those who cannot tolerate aspirin.
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✔️ Dosage & Administration | Napa One
Tablet (Immediate-Release):
- Adults: 1–2 tablets every 4–6 hours (max 4g/day or 8 tablets/day)
- Children (6–12 years): ½–1 tablet, 3–4 times daily (max 2.6g/day for long-term use)
Extended-Release Tablet:
- ≥12 years: 2 tablets every 6–8 hours (max 6 tablets/day); swallow whole
- Actizorb Technology Tablet (Fast-Acting):
- Adults & Children ≥12 years: 1–2 tablets every 4–6 hours (max 8 tablets/day)
- Children 7–11 years: ½–1 tablet every 4–6 hours (max 4 tablets/day)
Not recommended for children under 7 years
- Children ≥2 years: Safe and effective for fever and pain when dosed correctly
- Elderly: No significant difference in safety profile, but dose adjustment may be needed
- Hepatic/Renal impairment: Use lower doses with longer intervals
✔️ Drug Interactions
Alcohol, barbiturates, tricyclic antidepressants, and anticonvulsants may reduce metabolism or enhance liver toxicity risk.
Oral contraceptives and enzyme-inducing drugs may lower therapeutic levels due to increased first-pass metabolism.
✔️ Contraindications
Known allergy or hypersensitivity to Paracetamol.
✔️ Side Effects
Generally well tolerated. Rare side effects include:
- Blood disorders (e.g., thrombocytopenia, leukopenia, agranulocytosis)
- Skin reactions, rashes
- Pancreatitis or hypersensitivity reactions in some cases
✔️ Pregnancy & Lactation
- Considered safe during pregnancy when used in recommended doses.
- Paracetamol is excreted into breast milk in minimal amounts and is generally considered safe while breastfeeding.
✔️ Overdose Management
- Overdose (>10 g in adults) can cause severe liver damage
- Early symptoms include nausea, vomiting, abdominal pain, and pallor
- Liver injury may progress to hepatic failure, encephalopathy, or death within days
- Immediate treatment with activated charcoal (within 1 hour) and N-acetylcysteine (preferably within 8 hours) is critical
- In remote areas, oral Methionine may be an alternative
✔️ Precautions
- Use cautiously in patients with liver or kidney impairment
- Do not exceed the recommended dosage, especially in patients with alcoholism, malnutrition, or dehydration
- Avoid concurrent use with other Paracetamol-containing products
- Discontinue immediately if any allergic reaction or anaphylaxis occurs
✔️ Storage:
Store in a cool, dry place, away from light and heat
Keep out of reach of children
⚠️Disclaimer:
At ePharma, we’re committed to providing accurate and accessible health information. However, all content is intended for informational purposes only and should not replace medical advice from a qualified physician. Please consult your healthcare provider for personalized guidance. We aim to support, not substitute, the doctor-patient relationship.
